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Seminal Papers

The most cited cardiothoracic surgery papers

1.     Roach GW, Kanchuger M, Mangano CM et al (1996) Adverse cerebral outcomes after coronary bypass surgery. Multicenter study of perioperative ischemia research group and the ischemia research and education foundation investigators. N Engl J Med 335(25):1857–1863


Highlights rates of cerebral deficit after CABG, including risk factors and outcomes.


2.     Yusuf S, Zucker D, Peduzzi P et al (1994) Effect of coronary artery bypass graft surgery on survival: overview of 10-year results from randomised trials by the coronary artery bypass graft surgery trialists collaboration. Lancet 344(8922):563–570


Showed a significant outcome benefit in high- and medium-risk patients undergoing CABG vs medical therapy. 


3.     Leon MB, Smith CR, Mack M et al (2010) Transcatheter aorticvalve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 363(17):1597–1607


Showed that in patients with severe aortic stenosis that were not candidates for surgery, transcatheter valve implantation showed significant improvement vs standard therapy in reduction of mortality, repeat hospitalization, and cardiac symptoms, despite higher incidence of major strokes and vascular events



4.     Serruys PW, Morice MC, Kappetein AP et al (2009) Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med 360(10):961–972


SYNTAX trial: compared CABG vs PCI in patients with three-vessel of left main coronary artery disease and found that CABG remained the standard of care in these populations due to a reduction in major adverse cardiac or cerebrovascular events at 1 year. 



5.     Kirklin JK, Westaby S, Blackstone EH, Kirklin JW, Chenoweth DE, Pacifico AD (1983) Complement and the damaging effects of cardiopulmonary bypass. J Thorac Cardiovasc Surg 86(6):845–857


Demonstrated that the damaging effects of cardiopulmonary bypass are related to a whole-body inflammatory reaction.



6.     Chenoweth DE, Cooper SW, Hugli TE, Stewart RW, Blackstone EH, Kirklin JW (1981) Complement activation during cardiopulmonary bypass: evidence for generation of C3a and C5a anaphylatoxins. N Engl J Med 304(9):497–503


Revealed that inflammatory mediators are produced during extracorporeal circulation and that they contribute to ‘post-pump syndromes’



7.     Carpentier A (1983) Cardiac valve surgery–the ‘‘French correction’’. J Thorac Cardiovasc Surg 86(3):323–337


Highlighted novel techniques of mitral valve repair



8.     Alderman EL, Fisher LD, Litwin P et al (1983) Results of coronary artery surgery in patients with poor left ventricular function (CASS). Circulation 68(4):785–795


Found that in patients with coronary artery disease and ejection fraction <36% and abnormal wall motion, surgical treatment was beneficial for survival and for relief of angina. 



9.     Mishra J, Dent C, Tarabishi R et al (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365(9466):1231–1238


Discovered that urine and serum concentrations of neutrophil gelatinase-associated lipocalin (NGAL) are highly sensitive and specific for and predictive of acute renal injury after cardiac surgery

10.   Inoue K, Owaki T, Nakamura T, Kitamura F, Miyamoto N (1984) Clinical application of transvenous mitral commissurotomy by a new balloon catheter. J Thorac Cardiovasc Surg 87(3):394–402


Introduced the procedure of mitral commissurotomy without thoracotomy for management of mitral stenosis

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